Endocrine Abstracts

The patients with polycystic ovary syndrome (PCOS) are at increased risk for insulin resistance, central obesity, dyslipidemia and hypertension. In our study, we aimed to detect whether women with PCOS who had normal OGTT results have had insulin resistance. Moreover we investigated the association of probable insulin resistance with cardiovascular risk indicators such as hs-CRP and carotid intima media thickness (CIMT).In total, 34 untreated PCOS patien...

Obesity is due to the combined effects of genetic, environmental, lifestyle and the interactions of these factors. Leptin (LEP) is an adipocyte-derived hormone that acts to reduce food intake and increase energy expenditure by binding and activating its specific receptor in the hypothalamus. In humans, LEP and LEPR have been mapped to 7q31.3 and lp31, respectively. The LEP and LEPR genes have been investigated in the search for gene variants potentially related to the pathophy...

Overt hypothyroidism is associated with an increased risk for cardiovascular disease. We aimed in this study, to assess the changes in renal function, serum lipids, vitamin B12, folate and homocysteine levels before and after treatment in hypothyroid patients.Fifty-four (male/female;7/47) hypothyroid patients enrolled to study. We measured homocysteine(tHcy), total cholesterol(TC), triglyceride(TG), HDL-cholesterol (HDL-C), creatinine, folic acid, and vi...

Homozygous familial hypercholesterolemia (HoFH) represents a potentially fatal condition that is caused by low density lipoprotein (LDL) cholesterol receptor deficiency. Statins alone are not effective in HoFH. In recent years, semiselective or selective LDL cholesterol apheresis systems have been shown to prolong life. However, applying LDLC apheresis therapy, recent evidence also suggests that more intense LDL cholesterol reduction is associated with more clinical benefit. E...

C-reactive protein (CRP) is a non-specific but sensitive marker of underlying systemic inflammation. High CRP levels correlate with risk for future cardiovascular events. Statins can lower the circulating levels of CRP. In contrast, the evidence that fibrates lower CRP levels is very limited. This retrospective study evaluates the effect of micronised fenofibrate on plasma levels of CRP in patients with combined hyperlipidemia.Sixty-four patients with co...

Numerous clinical manifestations have been described in association with Cushing’s disease (CD). There was no eligible data on pulmonary function tests in CD patients. We aimed to assess pulmonary function test included spirometry in a series of patients with active Cushing’s disease (2 men, 9 women). Mean age, height, weight, body mass index were 36.7±12.6 (range 22–63 years), 156.9±8.4 cm, 74.1±10.7 kg, 29.6±3.8 kg/m2, respective...

Objective: Patients with hyperthyroidism occasionally need rapid restoration to the euthyroid state. In wiew of the increased enterohepatic circulation of thyroxine (T4) and triiodothyronine (T3) in thyrotoxicosis, and metabolic effects of konjac glucomannan in gastrointestinal system, we aimed to determine the activity of glucomannan in treatment of hyperthyroidism.Methods: A prospective, randomized, placebo-controlled, one-blind study design was used w...

Combined hyperlipidemia is characterized by elevated levels of total cholesterol, low density lipoprotein (LDL), triglyceride and mild decrease in high density lipoprotein (HDL) cholesterol. It is difficult to achieve desirable decreases of LDL cholesterol, triglycerides and increasing of HDL cholesterol with monotherapy in patients with mixed hyperlipoproteinemia. This retrospective study was carried out to assess the safety atorvastatin-fenofibrate combination therapy.<p...

Polycystic ovary syndrome (PCOS), affects approximately 5% to 10% all women. Insulin resistance is highly associated with this syndrome. Insulin resistance is associated with increased oxidation of low density lipoprotein (LDL) cholesterol. Oxidized LDL autoantibody levels are generally measured to evaluate the degree of LDL oxidation. In the present study, we aimed to measure serum titers of oxidized LDL autoantibodies in patients with PCOS.Twenty-five ...